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Rinkoo D Gupta

Associate Professor (SG)
PhD (Banaras Hindu University, 2005)
Protein Science Laboratory Click to visit ....Laboratory

Contact Details

rdgupta(at)sau.ac.in
South Asian University ,Rajpur Rd, Maidan Garhi, New Delhi, Delhi 110068
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Profile

  • Associate Professor (SG), South Asian University, New Delhi (2023-cont.)
  • Associate Professor, South Asian University, New Delhi (2019-2023)
  • Assistant Professor (SG), South Asian University, New Delhi (2016-2019)
  • Assistant Professor, South Asian University, New Delhi (2011-2016)
  • Research Associate, Institute of Genomics and Integrative Biology, Delhi (2010-2011)
  • Postdoctoral Fellow, Weizmann Institute of Sciences, Israel (2006-2009)
  • Senior Research Fellow, Banaras Hindu University, Varanasi, India (2005-2006)

Qualifications

  • Ph.D. in Zoology, from the Department of Zoology, Banaras Hindu University , 2005
  • M.Sc. in Zoology, from the Department of Zoology, Banaras Hindu University , 2001
  • B.Sc. in Chemistry, Botany and Zoology (Hons.), from MMV, Banaras Hindu University, 1999

Research Interests

My research group in the Protein Science Laboratory is dedicated to design and produce novel therapeutic agents by applying different rational protein designing approaches. Protein Engineering has enormous potential to provide new diagnostic and therapeutic proteins for medical applications in the form of antibodies, vaccines and enzymes. Currently, we are focusing on the following goals-

  • Designing and production of Monoclonal Antibodies (scFv and humanized) against the envelope protein of Dengue virus
  • Development of Short-Peptide Vaccine against Dengue virus for enhanced immunogenicity and low antibody-dependent enhancement (ADE)
  • Redesigning human Lactonases (PONs and SMP30) for organophosphate degradation and anti-biofilm property
  • Characterization of bacterial and human Chitinases for enhanced anti-fungal, and anti-cancer properties

Recent Publications

  •     Shrivastava A, Goel M, Khalid MF, Sharma G, Khandelwal A, Sharma D, & Gupta RD*. Evaluation of the Recombinant Bacterial Chitinases as Anti-proliferative and Anti-migratory Agents for the Human Breast Cancer Cell Line, MCF-7. Applied Biochemistry and Biotechnology. Published online February 23, 2024. doi:10.1007/s12010-024-04888-5, PMID: 38393581
  •     Yadav P, Goel M, Gupta RD*. Anti-biofilm Potential of Human Senescence Marker Protein 30 against Mycobacterium smegmatis. World Journal of Microbiology and Biotechnology, December 2023, 40-45 (1-13). doi: 10.1007/s11274-023-03843-6, PMID: 38114754
  •      Sarker A, Dhama N, Gupta RD*. Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement. Frontiers in Immunology, 2023 Jun 2;14:1200195. doi: 10.3389/fimmu.2023.1200195. PMID: 37334355.
  •      Chaturvedi M, Joy S, Gupta RD, Pandey S, Sharma S.  Endocrine Disrupting Chemicals (EDCs): Chemical fate, Distribution, Analytical methods and Promising Remediation Strategies - A Critical Review. Environmental Technology Reviews. 2023, 12(1): 286-315, doi: 10.1080/21622515.2023.2205026
  •       Sarker A, Rathore AS, Khalid MF, Gupta RD*. Structure-guided affinity maturation of a single-chain variable fragment antibody against the Fu-bc epitope of the dengue virus envelope protein. Journal of Biological Chemistry. 2022 Feb 23:101772. doi: 10.1016/j.jbc.2022.101772. PMID: 35218775
  •    Parween F, Yadav P, Singh K, Gupta RD*. Production of highly soluble native human paraoxonase 2 with potential anti-biofilm property. Preparatory Biochemistry and Biotechnology. 2022 Jul 20:1-10. doi: 10.1080/10826068.2022.2101000. 1.    PMID: 35856452.

  •       Parween F, Sarker A, Gupta RD*. Chlorpyrifos and parathion regulate oxidative stress differentially through the expression of paraoxonase 2 in human neuroblastoma cell. NeuroToxicology. 2022 Sep 1;93:60-70. doi: 10.1016/j.neuro.2022.08.016. PMID: 36058312.
  •       Parween F, Gupta RD*. Insights into the role of paraoxonase 2 in human pathophysiology. Journal of Biosciences. 2021; 46:4. doi: 10.1007/s12038-021-00234-7. PMID: 34987135.
  •       Parween F, Hossain MS, Singh KP, Gupta RD*. Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease. PLoS One. 2021 Oct 29; 16(10): e0258879. doi: 10.1371/journal.pone.0258879. PMID: 34714861
  •     Deswal N, Shrivastava A, Hossain MS, Gahlyan P, Bawa R, Gupta RD and Kumar R. Design, Synthesis, Evaluation and Molecular Docking Studies of Novel Triazole Linked 1,4‐Dihydropyridine‐isatin Scaffolds as Potent Anticancer Agents. January 2021, ChemistrySelect 6(4):717-725, doi: 10.1002/slct.202003948
  •      Mukherjee S, Gupta RD*. Organophosphorus Nerve Agents: Types, Toxicity, and Treatments. Journal of Toxicology. 2020 Sep 22; 2020:3007984. doi: 10.1155/2020/3007984. PMID: 33029136
  •      Hossain MS, Dutta RK, Muralidhar K, Gupta RD*. Decreased ascorbic acid biosynthesis in response to PMSG in the pre-pubertal female rat ovary. Research in Veterinary Science, 2020 Apr 4;131:15-20. doi: 10.1016/j.rvsc.2020.03.028, PMID: 32278959.
  •       Rathore AS, Sarker A, Gupta RD*. Production and immunogenicity of Fubc subunit protein redesigned from DENV envelope protein. Applied Microbiology and Biotechnology, 2020 May;104(10):4333-4344. doi: 10.1007/s00253-020-10541-y, PMCID: PMC7223326
  •      Agarwal D, Singh S, Gupta RD, Awasthi SK. In vitro synergistic interaction of potent 4-aminoquinolines in combination with dihydroartemisinin against chloroquine-resistant Plasmodium falciparum. Acta Tropica, 2019 Jul 24:105109. doi: 10.1016/j.actatropica.2019.105109, PMID: 31351071.
  •      Dutta RK, Parween F, Hossain MS, Dhama N, Pandey P, Gupta RD*. Comparative analysis of the metal-dependent structural and functional properties of Mouse and Human SMP30. PLoS One. 2019, Jun 20;14(6):e0218629. doi: 10.1371/journal.pone.0218629. PMID: 31220150.
  •       Sarker A, Rathore AS, Gupta RD*. Evaluation of scFv protein recovery from E. coli by in vitro refolding and mild solubilization process. Microbial Cell Factories. 2019 Jan 14;18(1):5.  doi: 10.1186/s12934-019-1053-9. PMID: 30642336.
  •        Rathore AS, Sarker A, Gupta RD*. Designing antibody against highly conserved region of dengue envelope protein by in silico screening of scFv mutant library. PLoS One. 2019 Jan 10; 14(1):e0209576. doi: 10.1371/journal.pone.0209576. PMID: 30629625.
  •      Rathore AS, Sarker A, Gupta RD*. Recent developments toward antibody engineering and affinity maturation. Protein and Peptide Letters, 2018, 25 (10): 886-896. PMID: 30255742.
  •        Rathore AS, Gupta RD* (2015) Chitinases from Bacteria to Human: Properties, Applications, and Future Perspectives. Enzyme Research, 2015(2):1-8. doi: 10.1155/2015/791907
  •      Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I, Sussman JL and Tawfik DS (2011) Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nature Chemical Biology 02/2011; 7(2):120-5. doi: 10.1038/nchembio.510
  •      Gupta RD and Tawfik DS. Directed enzyme evolution via small and effective neutral drift libraries. Nature Methods . 11/2008; 5(11):939-42. doi: 10.1038/nmeth.1262

Awards & Honours

  • Fellowship from the DST’s FAST track scheme for young scientists in Life Sciences (2012)
  • Fellowship from the DST’s FAST track scheme for young scientists in Chemical Sciences (2011)
  • CSIR-Research Associate Fellowship (2010)
  • Post-Doctoral Fellowship from the Weizmann Institute of Sciences (2006)
  • CSIR-Senior Research Fellowship (2004)
  • CSIR –Junior Research Fellowship (2002)

Patents:

  •   Rinkoo D. Gupta, Animesh Sarker, Abhishek S Rathore “An Antibody or An Antigen Binding Fragment Thereof Against Dengue” Indian patent Application No.: 202111017607 filed on 15th April 2021, and published on 24th February, 2023.
  •  Dan S Tawfik, Rinkoo D Gupta, Moshe Goldsmith, Yaacov Ashani, Israel silman, Ben-David, Joel Sussman (2011) “Isolated PON1 Polypeptides, Polynucleotides Encoding Same and Uses Thereof in Treating or Preventing Organophosphate Exposure Associated Damage”. Ref. No: WO/ 2011/033506 /A2, Year: 03/2011.

Last Updated : 25 Jun 2024