South Asian University ,Rajpur Rd, Maidan Garhi, New Delhi, Delhi 110068
Profile
ACADEMIC APPOINTMENTS:
Professor, FLSB, SAU, 2011 to date
Vice President, South Asian University, New Delhi (2010 to 2016)
Professor and Dean: FLSB, South Asian University, New Delhi (2010 to 2016)
Rector (Pro Vice-Chancellor): Jawaharlal Nehru University, New Delhi (2002-2005)
Dean: SLS, Jawaharlal Nehru University, New Delhi (From 2001-2002)
Professor of Immunology: SLS, Jawaharlal Nehru University, New Delhi (1991-2010)
Officer on Special Duty: South Asian University, New Delhi (2008-2010)
Visiting Professor: University of Pittsburgh School of Medicine, PA, USA (1990-1992); NIOSH, CDC, WV, USA (1999-2001); US-EPA, Durham, North Carolina, USA (2005-2007).
Post Doctoral Fellow: NIA, NIH, USA (1978-1984)
Qualifications
PhD in Biochemistry from All India Institute of Medical Sciences, New Delhi , in 1977
M.Sc. in Biochemistry from All India Institute of Medical Sciences, New Delhi , in 1973
Research Interests
Natural and adaptive Immune response in lungs
Interactions of nanoparticles with living systems
Ontogeny of erythrocytes and their turnover in blood
Recent Publications
Behera, S.P, Tyagi, W. and Saxena, R. K. (2023) Inhibition of cellular motility and invasiveness of B16F10 melanoma cells by carboxyl-nanodiamonds, blocks metastasis of this tumor (under publication)
Bhardwaj and Saxena, R.K. (2023) Down-regulation of pro-inflammatory genes by carbon nanoparticles results in the suppression of mono sodium urate induced inflammatory response in macrophages (under publication)
BabuMia Md, Pushpam D, Bakhshi S, Saxena RK (2022) Uptake of Poly-dispersed Carbon Nanotubes Induce Cytotoxic and Cytostatic Effect on Human B Cell Leukemia Cells. J ClinToxicol. 12:504.
Behera, S.P. and Saxena, R.K. (2021)Nanodiamonds inhibit the scratch wound healing process in Lung Epithelial Cell Monolayers by inhibiting cell proliferation and migration.Toxicology Letters 341, 83-93
Babu Mia, Md. And Saxena, R.K. (2021) Poly-dispersed single-walled carbon nanotubes induce cytotoxicity in bone marrow derived Hematopoietic Stem and Progenitor Cells and modulate their cytokine driven differentiation to immune cells. Current Res. Toxicology 2, 82-92
Bhardwaj, D. and Saxena, R.K. (2021) Poly-dispersed-acid-functionalized-single-walled carbon nanotubes (AF-SWCNTs) are potent inhibitor of BCG induced inflammatory response in macrophages. Inflammation DOI 10.1007/s10753-020-01386-8
Bhardwaj, D. and Saxena, R.K. (2020) Uptake of diamond nanoparticles blocks inflammatory responses in macrophages. International J. Nanotechnology in Medicine and Engineering Volume 5 Issue 4, October 2020
Behera, S.P. and Saxena, R.K. (2020)Suppression of in Vitro Wound Healing Process in Monolayers of Lung Epithelial Cells by Poly-dispersed-acid-functionalized-single-walled Carbon Nanotubes and Its Mechanism. International J. Nanotechnology in Medicine and Engineering,Volume 5 Issue 3, September 2020
Babu Mia, Md. And Saxena, R.K. (2020) Poly dispersed acid-functionalized single walled carbon nano-tubes target activated T and B cells to suppress acute and chronic GVHD in mouse model. Immunology Letters 224, 30-37
Babu Mia, Md. And Saxena, R.K. (2020) In vitro and in vivo modulation of Hematopoietic Stem Cell (HSCs) differentiation into T and B cells by poly dispersed acid-functionalized single-walled carbon nanotubes (AF-SWCNTs) J Immunol, May 1, 2020, 204 (Supplement) 62.131
Bhardwaj, D. and Saxena, R.K. (2020) Poly-dispersed-acid-functionalized-single-walled carbon nanotubes(AF-SWCNTs) are potent inhibitor of BCG induced inflammatory response in macrophage cell lines. BIORXIV/2020/056960
Behera, S.P and Saxena, R. K. (2020) Modulation of cell adhesion and migration by poly-dispersed-acid-functionalized-single-walled carbon-nanotubes in lung epithelial cells BIORXIV-2020-056895v2
Dutt, T.S. and Saxena, R.K. (2020) Enhanced antibody response to ovalbumin coupled to poly-dispersed acid functionalized single walled carbon nanotubes. Immunology Letters217, 77-83
Singh, A. P., Md. Babu Mia and Saxena, R.K.(2020) Acid-functionalized single walled carbon nanotubes alter epithelial tight junctions and enhance para-cellular permeability. J. Biosciences45, 23
Dutt, T.S. and Saxena, R.K. (2019) Uptake of Carboxylated Fluorescent Nano-Diamonds by Resting and Activated T and B Lymphocytes and Comparison with Carbon Nanotube Uptake, International Journal of Nanotechnology in Medicine & Engineering 4:7, 61-68
Dutt, T.S. and Saxena, R.K. (2019) Activation of T and B lymphocytes Induces Increased Uptake of Poly-Dispersed single-Walled Carbon Nanotubes and Enhanced Cytotoxicity. International Journal of Nanotechnology in Medicine & Engineering 4:3, 16-25
Dutt, T.S., Babu Mia, Md. and Saxena, R.K. (2019) Elevated internalization and cytotoxicity of poly-dispersed single-walled carbon nanotubes in activated B cells can be basis for preferential depletion of activated B cells in vivo. Nanotoxicology, 2019,DOI: 10.1080/17435390.2019.1593541)
Babu Mia, Md. and Saxena, R.K. (2018) Phosphatidyl serine externalization in different age groups of mouse erythrocytes in response to agents that induce anemia. Hematol Transfus Int J. 6(4):144‒149.
Alam, A., Puri, N. and Saxena, R.K. (2016) Uptake of poly-dispersed single-walled carbon nanotubes and decline of functions in mouse NK cells undergoing activation,J.Immunotoxicology, DOI: 10.1080/1547691X.2016.1191562
Chaterjee, S. and Saxena, R.K. (2016) Identification of stages of erythroid differentiation in bone marrow and erythrocyte subpopulations in blood circulation that are preferentially lost in autoimmune hemolytic anemia in mouse PLoS One 11(11): e0166878. doi:10.1371/journal.pone.0166878
Chaterjee, S. and Saxena, R.K. (2015) Preferential elimination of older erythrocytes in circulation and depressed bone marrow erythropoietic activity contribute to cadmium induced anemia in mice. PLoS One 10 (7): e0132697. doi:10.1371/ journal. pone.0132697
Kumari, M. and Saxena, R.K. (2015) Proliferative activity and changes in the relative proportion of T1 and TII populations in cultured primary epithelial cells, isolated from mouse lung. Cell Biology: Research and Therapy 4:3. doi:10.4172/2324-9293.1000121
Bhardwaj N. and Saxena R. K. (2015) Selective loss of younger erythrocytes from blood circulation and changes in erythropoietic patterns in bone marrow and spleen in mouse anemia induced by poly-dispersed single wall carbon nanotubes. Nanotoxicology 9(8):1032-40.
Bhardwaj N. and Saxena R. K. (2014) Elimination of young erythrocytes from blood circulation and altered erythropoietic patterns during paraquat induced anemic phase in mice. PLoS ONE 9(6): e99364
Abbas, Z., Puri, N. and Saxena, R.K. (2014) Lipid antigen presentation through CD1d pathway in mouse lung epithelial cells, macrophages and dendritic cells and its suppression by poly-dispersed single-walled carbon nanotubes. Toxicology in vitro 29(6):1275-82
Bhardwaj N. and Saxena R. K. (2013) Heterogeneity of reticulocyte population in mouse peripheral blood. Current Science 105, 1611-1614.
Alam, A., Sachar, S., Puri, N. and Saxena, R.K. (2013). Interactions of poly-dispersed single walled Carbon Nanotubes with T cells resulting in down regulation of allogeneic CTL responses in vitro and in vivo. Nanotoxicology 7, 1351-1360 [Included as a Key Nanotechnology Articles on Global Medical Discovery web-portal (globalmedicaldiscovery.com]
Saxena, R.K., Bhardwaj, N, Sachar, S, Puri, N. and Khandelwal, S (2012) A double in vivo biotinylation (DIB) technique for objective assessment of aging and clearance of mouse erythrocytes in blood circulation, Transfusion Medicine and Hemotherapy 39, 335-341
Kumari, M., Sachar, S. and Saxena, R.K. (2012) Loss of proliferative and antigen presentation activity following internalization of poly-dispersed single-walled carbon nanotubes by primary lung epithelial cells PLOS one 7 (2): e31890
Sachar, S and Saxena R.K. (2011). Cytotoxic effect of poly-dispersed single walled carbon nano-tubes on erythrocytes. PLOS one 6 (7): e22032
Kumari, M. and Saxena, R.K. (2011) . Relative efficacy of uptake and presentation of BCG antigens by type I mouse lung epithelial cells and peritoneal macrophages . Infection and Immunity 79:3159-67
Saxena, R.K., McClure, M, Hays, M., Green, F.H.Y., McPhee, L.J., Vallyathan, V. and Gilmour, M.I. (2010) . Quantitative assessment of elemental carbon in the lungs of never smokers, cigarette smokers and coal miners. J. Toxicol. Environ. Health . 74: 706-715.
Saxena, R.K., Gilmour, M.I., Schladweiler, M.C., McClure, M., Hays, M. and Kodavanti, U.P. (2009). Differential Pulmonary Retention of Diesel Exhaust Particles in Wistar Kyoto and Spontaneously Hypertensive Rats . Toxicological Sci. 111:392-401.
Saxena, R.K., Gilmour, M.I. and Hays, M.D. (2008) Isolation and quantitative estimation of diesel exhaust and carbon black particles ingested by lung epithelial cells and alveolar macrophages in vitro . BioTechniques ,44: 799-805.
Saxena, R.K., Williams, W., McGee, J.K., Daniels, M.J., Boykin, E. and Gilmour, M.I. (2007) .Enhanced in vitro and in vivo toxicity of poly-dispersed acid-functionalized single-wall carbon Nanotubes . Nanotoxicology , 1: 291-300.
Awards & Honours
Prof. TR Sheshadri Award by Delhi University at Delhi, in 1970
