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Priti Saxena

Assistant Professor (SG)
PhD (National Institute of Immunology, New Delhi, 2008)
Chemical Biology Group Click to visit ....Laboratory

Contact Details

psaxena(at)sau.ac.in
South Asian University ,Rajpur Rd, Maidan Garhi, New Delhi, Delhi 110068

Profile

RESEARCH EXPERIENCE:

  • Senior Assistant Professor: South Asian University, New Delhi (October 2018 onwards)

  • Assistant Professor: South Asian University, New Delhi (2011-2018)

  • Scientist Fellow: Institute of Genomics and Integrative Biology, Delhi (2009-2011)

  • Research Associate: National Institute of Immunology (NII), New Delhi (2008-2009)

  • Research Fellow: National Institute of Immunology (NII), New Delhi (2000-2003)

RESEARCH INTERESTS:

  • Chemical Biology: Molecular Mechanisms of host pathogen interactions in mycobacterial diseases, Bio-manufacturing of functionally important and structurally diverse polyketides

Qualifications

  • PhD in Chemical Biology from National Institute of Immunology, New Delhi, in 2008
  • MSc in Microbiology from Institute of Microbiology and Biotechnology, Barkatullah University, Bhopal, in 2000
  • BSc in Chemistry, Botany, Zoology from Sri Sathya Sai College, Barkatullah University, Bhopal, in 1998

 

Research Interests

  • Chemical Biology: Molecular Mechanisms of host pathogen interactions in mycobacterial diseases, Bio-manufacturing of functionally important and structurally diverse polyketides

Recent Publications


  • R. Giri and P. Saxena*, Mycobacterial Mmar_2193 catalyzes O-methylation of diverse polyketide cores. PLOS One, doi.org/10.1371/journal.pone.0262241, (January 2022)
  • Bisht, A. Bhattacharyya, A. Shrivastava and P. Saxena*, An overview of the medicinally important plant type III PKS derived polyketides. Frontiers in Plant Science 12:746908. doi: 10.3389/fpls.2021.746908, (October 2021)
  • Bisht R and Saxena P*. Antibiotic Abuse: Post-antibiotic apocalypse, Superbugs & Superfoods, Current Science, Vol. 116, No. 7, (April 10, 2019)
  • Saxena P*, Joshi Y, Rawat K, and Bisht R. Biofilms: architecture, resistance, quorum sensing and control mechanisms, Indian Journal of Microbiology. (March 2019), Volume 59, Issue 1, pp 3–12.
  • Yelamanchi, S. D., Tyagi, A., Mohanty, V., Dutta, P., Korbonits, M., Chavan, S., Advani, J., Madugundu, A. K., Dey, G., Datta, K. K., Rajyalakshmi, M., Sahasrabuddhe, N. A., Chaturvedi, A., Kumar, A., Das, A. A., Ghosh, D., Jogdand, G. M., Nair, H. H., Saini, K., Panchal, M., Sarvaiya, M. A., Mohanraj, S. S., Sengupta, N., Saxena, P, Subramani, P. A., Kumar, P., Akkali, R., Reshma S. V., Santhosh, R. S., Rastogi, S., Kumar, S., Ghosh, S. K., Irlapati, V. K., Srinivasan, A., Radotra, B. D., Mathur, P. P., Wong, G. W., Satishchandra, P., Chatterjee, A., Gowda, H., Bhansali, A., Pandey, A., Shankar, S. K., Anita Mahadevan, A., Prasad, T. S. K.. Proteomic analysis of the human anterior pituitary gland. OMICS: A Journal of Integrative Biology. (November 2018)
  • Pratap, S., Kant, A., Giri, S., Giri, G.R., Saxena, P.*, Krishnan, V.*. Crystal structure of type III polyketide synthase from Mycobacterium marinum, PDB ID: 5ZQ9, RCSB Protein Data Bank. (2018).
  • Parvez, A., Giri, S., Bisht, R. & Saxena, P.*. New Insights on Cyclization Specificity of Fungal Type III Polyketide Synthase, PKSIIINc in Neurospora crassa, Indian Journal of Microbiology. (April 27, 2018). doi: 10.1007/s12088-018-0738-9.
  • Parvez, A., Giri, S., Giri, G.R., Kumari, M., Bisht, R. & Saxena, P.*. Novel Type III Polyketide Synthases Biosynthesize Methylated Polyketides in Mycobacterium marinum, Nature Scientific Reports. 8(1):6529, (April 25 2018).doi:10.1038/s41598-018-24980-1.
  • Parvez, A., Bisht, R. & Saxena, P.*. Classification of Bacterial Type III Polyketide Synthases on the Basis of Cluster Organization in the Genome, Conference Proceedings of iCiAsT-2016, Bangkok, Thailand, February 1-5 (2016).
  • Saxena, P.∞, Goyal, A. ∞, Rahman, A., Singh, P.K., Kasbekar, D.P., Gokhale, R.S. & Sankaranarayanan, R. Structural insights into biosynthesis of resorcinolic lipids by a type III polyketide synthase in Neurospora crassa, Journal of Structural Biology. 162(3):411-421, June (2008). (∞ equal authorship)
  • Gokhale, R.S., Saxena, P., Chopra, T. & Mohanty, D. Versatile polyketide enzymatic machinery for biosynthesis of complex mycobacterial lipids, Natural Product Reports. 24(2):267-277, April (2007).
  • Krithika, R., Marathe, U., Saxena, P., Ansari, M.Z., Mohanty, D. & Gokhale, R.S. A genetic locus required for iron acquisition in Mycobacterium tuberculosis, Proceedings of the National Academy of Sciences, USA. 103(7):2069, February 14 (2006).
  • Arora, P., Vats, A., Saxena, P., Mohanty, D. & Gokhale, R.S. Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis, Journal of the American Chemical Society. Vol. 127, No. 26, July 6, pp. 9388-9389 (2005).
  • Sankaranarayanan, R., Saxena, P., Marathe, U.B., Gokhale, R.S., Shanmugam, V.M. &Rukmini, R. A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites, Nature Structural & Molecular Biology, Vol. 11, No. 9, September 9, pp. 894-900 (2004).
  • Rukmini, R., Shanmugam, V.M., Saxena, P., Gokhale, R.S. & Sankaranarayanan, R. Crystallization and preliminary X-ray crystallographic investigations of an unusual type III polyketide synthase PKS18 from Mycobacterium tuberculosis, ActaCrystallographica D Biological Crystallography. Vol. 60, Part 4, April, pp. 749-751, (2004).
  • Saxena, P., Yadav, G., Mohanty, D. &Gokhale, R.S. A new family of type III polyketide synthases in Mycobacterium tuberculosis, The Journal of Biological Chemistry, Vol. 278, No. 45, November 7, pp. 44780-44790 (2003).

 

Patents:

 

  • Patent Granted by IPO, India, Patent Number: 475858, Title: Methodology for Production of Acylphloroglucinol or Analogues using Microorganisms, Inventors: Saxena, P., Parvez, A., Giri, G.R., Bisht, R., Giri, S. Applicants: SAU & DBT, GoI (IPA No.: 201811013921, Filing: 24/07/18, Published: 31/01/2020, FER Response: 28/03/2022, Hearing: 06/11/2023, Date of Grant: 30/11/2023)
  • Title: Methodology for Production of Alkylresorcinol or Analogues using Microorganisms, IPA No.: 201811013918, Complete filing: 24/07/19, Inventors: Saxena, P., Parvez, A., Giri, G.R., Bisht, R., Giri, S. Applicants: SAU & DBT, GoI (Published 31/01/2020, Under Examination)
  • Title: Biosynthesis of Multimethylated Molecules using Recombinant Vectors and Strains, IPA No.: 202011027652, Provisional filing: 26.09.2020, Inventors: Saxena, P., and Giri, G.R. Applicant: SAU (Filed)
  • Title: Recombinant Vectors and Strains for Biosynthesis of Multimethylated Molecules, IPA No.: 202111060746, Provisional filing: 24.12.2021, Inventors: Saxena, P., Giri, G.R., and Hathi, U.P.S Applicant: SAU (Filed)

Awards & Honours

  • Innovative Young Biotechnologist Award (IYBA) by the Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India.
  • SAU Start-Up Research Grant by South Asian University (SAU), New Delhi, India.
  • Core Research Grant (CRG) by Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India.
  • Awarded the ‘Best Speaker Award’ in Young Scientist category for presenting the talk entitled “Molecular Diversity in Mycobacterial Pathogenesis” at UGC-Resource Networking National Symposium on ‘Microbes in Health and Agriculture’, MHA-2012, organized by School of Life Sciences, Jawaharlal Nehru University, New Delhi, India during March 12-13, 2012
  • Honored with ‘Science Initiator Award – 2015’ for presenting the work entitled “Mechanistic Versatility of Corynebacterineae Type III Polyketide Synthases” at the ‘International Conference on Innovative Approaches in Applied Sciences and Technologies’ (iCiAsT-2016) organized at Kasetsart University, Bangkok, Thailand during February 1-5, 2016
  • ‘AMI J. S. Bhatt Best Paper Award’ for most citations of review article entitled, ‘Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms’ published in INJM. The Association of Microbiologists of India (AMI)
  • Best Poster Award (First Place) received for e-poster presented on 'Functional Flexibility of Mycobacterium marinum Type III Polyketide Synthases and Modifying Enzymes' at the International Symposium on 'Innovative Approaches in Global Health: Linking Epidemiology and Biomarkers' held on December 9, 2023 jointly organized by the Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, and Department of Community Medicine, Yenepoya Medical College, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangaluru – 575018, Karnataka, India.
  • Patent Granted by IPO, India, Patent Number: 475858, Title: Methodology for Production of Acylphloroglucinol or Analogues using Microorganisms, Inventors: Saxena, P., Parvez, A., Giri, G.R., Bisht, R., Giri, S. Applicants: SAU & DBT, GoI (IPA No.: 201811013921, Filing: 24/07/18, Published: 31/01/2020, FER Response: 28/03/2022, Hearing: 06/11/2023, Date of Grant: 30/11/2023)

Last Updated : 20 May 2024